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Pain Syndromes

Co-morbid pain

Muscle and/or joint-related pain are among the most common reasons that people see their doctor. Part of the physician’s job is to determine causes of the pain. However, this can be difficult as there are many causes and types of pain as well as a variety of underlying pathologies. One of our goals is to understand why patients develop chronic pain because of acute trauma (e.g., whiplash, concussion, surgery). Another goal is to understand pain in patients who have osteoarthritis and may require joint replacement surgery. In collaboration with the University of Toronto, Toronto Western Hospital, and St. Joseph’s Healthcare Hamilton, we aim to characterize ‘patient phenotypes’ among total knee replacement candidates, including identifying potential surgery non-responders.


  • Duarte FCK, Hurtig M, Clark A, Simpson J, Srbely JZ, Association between naturally occurring spine osteoarthritis in geriatric rats and neurogenic inflammation within neurosegmentally linked skeletal muscle. Exp. Gerontol. 2019; 118:31-38.

  • Grosman-Rimon L, Parkinson W, Upadhye S, Clarke H, Katz J, Flannery J, Peng P, Kumbhare D. Circulating Biomarkers in Acute Myofascial Pain: A Case-Control Study.  Medicine 2016;95(37):4650.

  • Rathbone ATL, Tharmaradinam S, Jiang S, Rathbone MP, Kumbhare DA. A review of the neuro- and systematic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS. Brain, Behavior, and Immunity: 46: 1–16, 2015.

  • Kumbhare DA, Parkinson W, Dunlop RB.  Validity of serum creatine kinase for measuring muscle injury in lumbar surgery.  Journal of Spinal Disorders and Techniques: 21(1):49-54, 2008.

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